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One medicine used to treat male erectile dysfunction is Kamagra Gel. To help generate and sustain an erection during sexual intimacy, it increases blood flow to the penis. After taking it, it usually starts to work 30 to 60 minutes later, making it easier to have sex more naturally. It has a 4-hour half-life, which is long enough to provide enough time for sexual activity. Sildenafil can be taken with or without food. It will take longer for sildenafil to take effect, though, if you take it with a high-fat meal. Pay close attention to the instructions on your prescription label, and ask your pharmacist or doctor to clarify any parts you don't understand. When taking this medication, discuss with your doctor the possibility of consuming grapefruit and grapefruit juice.